藥物交互作用
Gemfibrozil + Ombitasvir / paritaprevir / ritonavir and dasabuvir
嚴重程度: 禁忌併用
Gemfibrozil and Ombitasvir / paritaprevir / ritonavir and dasabuvir: contraindicated interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Gemfibrozil strongly inhibits CYP2C8, which is the main route of dasabuvir clearance. Dasabuvir concentrations rise several-fold, raising concern for QT prolongation. The combination is contraindicated in labeling.
用白話說明這項交互作用的意義
Gemfibrozil and Ombitasvir / paritaprevir / ritonavir and dasabuvir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
為什麼會發生
Gemfibrozil and its glucuronide inhibit CYP2C8-mediated metabolism of dasabuvir, markedly increasing its plasma levels.
處置方式
Do not use together. Switch to a different lipid-lowering drug, such as fenofibrate or a statin, before starting the antiviral regimen.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Gemfibrozil 的其他交互作用
常見問題
Can I take Gemfibrozil with Ombitasvir / paritaprevir / ritonavir and dasabuvir?
MediHelp rates the interaction as contraindicated. Gemfibrozil and Ombitasvir / paritaprevir / ritonavir and dasabuvir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Gemfibrozil strongly inhibits CYP2C8, which is the main route of dasabuvir clearance. Dasabuvir concentrations rise several-fold, raising concern for QT prolongation. The combination is contraindicated in labeling.
How serious is the interaction between Gemfibrozil and Ombitasvir / paritaprevir / ritonavir and dasabuvir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together. Switch to a different lipid-lowering drug, such as fenofibrate or a statin, before starting the antiviral regimen.
What other medicines interact with Gemfibrozil?
MediHelp also lists interactions of Gemfibrozil with, for example, Daprodustat, Elagolix, Mavacamten. The full list is on the Gemfibrozil page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
