藥物交互作用
Gemfibrozil + Metformin-repaglinide
嚴重程度: 禁忌併用
Gemfibrozil and Metformin-repaglinide: contraindicated interaction.
最後更新
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摘要
Gemfibrozil and its glucuronide strongly inhibit CYP2C8 and OATP1B1, the main clearance pathways of repaglinide, raising repaglinide exposure several-fold. Prolonged and severe hypoglycaemia can result. The metformin component adds little to this effect.
用白話說明這項交互作用的意義
Gemfibrozil and Metformin-repaglinide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Gemfibrozil belongs to Cardiovascular; Metformin-repaglinide belongs to Endocrine.
為什麼會發生
CYP2C8/OATP1B1 inhibition markedly increases repaglinide exposure
處置方式
Contraindicated; use a different lipid-lowering agent or glucose-lowering drug and monitor glucose if the change is made.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Metformin-repaglinide 的其他交互作用
Gemfibrozil 的其他交互作用
常見問題
Can I take Gemfibrozil with Metformin-repaglinide?
MediHelp rates the interaction as contraindicated. Gemfibrozil and Metformin-repaglinide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Gemfibrozil and its glucuronide strongly inhibit CYP2C8 and OATP1B1, the main clearance pathways of repaglinide, raising repaglinide exposure several-fold. Prolonged and severe hypoglycaemia can result. The metformin component adds little to this effect.
How serious is the interaction between Gemfibrozil and Metformin-repaglinide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Contraindicated; use a different lipid-lowering agent or glucose-lowering drug and monitor glucose if the change is made.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Apalutamide, Clarithromycin, Clopidogrel. The full list is on the Metformin-repaglinide page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
