藥物交互作用
Gliclazide + Sulfamethoxazole
嚴重程度: 嚴重
Gliclazide and Sulfamethoxazole: major interaction.
最後更新
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摘要
Sulfamethoxazole, usually given as co-trimoxazole, can enhance the glucose-lowering effect of sulfonylureas and has been linked to serious hypoglycemia. Elderly patients and those with kidney disease are particularly vulnerable.
用白話說明這項交互作用的意義
Gliclazide and Sulfamethoxazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
為什麼會發生
Sulfamethoxazole inhibits CYP2C9, which metabolizes the sulfonylurea, and may displace it from protein binding.
處置方式
Monitor blood glucose closely, particularly in the first days of therapy, and lower the gliclazide dose if needed; consider an alternative antibiotic in high-risk patients.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Gliclazide 的其他交互作用
常見問題
Can I take Gliclazide with Sulfamethoxazole?
MediHelp rates the interaction as major. Gliclazide and Sulfamethoxazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Sulfamethoxazole, usually given as co-trimoxazole, can enhance the glucose-lowering effect of sulfonylureas and has been linked to serious hypoglycemia. Elderly patients and those with kidney disease are particularly vulnerable.
How serious is the interaction between Gliclazide and Sulfamethoxazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely, particularly in the first days of therapy, and lower the gliclazide dose if needed; consider an alternative antibiotic in high-risk patients.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
