藥物交互作用
Fluconazole + Gliclazide
嚴重程度: 嚴重
Fluconazole and Gliclazide: major interaction.
最後更新
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摘要
Fluconazole raises gliclazide exposure and can cause prolonged or severe hypoglycemia. Cases of hypoglycemia have been reported with azole antifungals and sulfonylureas.
用白話說明這項交互作用的意義
Fluconazole and Gliclazide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fluconazole belongs to Anti Fungals; Gliclazide belongs to Endocrine.
為什麼會發生
Fluconazole inhibits CYP2C9 and CYP2C19, which metabolize gliclazide, reducing its clearance.
處置方式
Monitor blood glucose closely and reduce the gliclazide dose during fluconazole therapy. Consider an alternative antifungal if glycemic control is difficult.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Gliclazide 的其他交互作用
Fluconazole 的其他交互作用
常見問題
Can I take Fluconazole with Gliclazide?
MediHelp rates the interaction as major. Fluconazole and Gliclazide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fluconazole raises gliclazide exposure and can cause prolonged or severe hypoglycemia. Cases of hypoglycemia have been reported with azole antifungals and sulfonylureas.
How serious is the interaction between Fluconazole and Gliclazide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely and reduce the gliclazide dose during fluconazole therapy. Consider an alternative antifungal if glycemic control is difficult.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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