藥物交互作用
Disopyramide + Gliclazide
嚴重程度: 嚴重
Disopyramide and Gliclazide: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Disopyramide can cause hypoglycemia, sometimes severe, and may add to the effect of gliclazide. Elderly patients and those with renal impairment are at greater risk.
用白話說明這項交互作用的意義
Disopyramide and Gliclazide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Disopyramide belongs to Cardiovascular; Gliclazide belongs to Endocrine.
為什麼會發生
Disopyramide stimulates insulin secretion through effects on pancreatic potassium channels, additive with sulfonylureas.
處置方式
Monitor blood glucose closely and reduce the gliclazide dose if needed; consider an alternative antiarrhythmic if recurrent hypoglycemia occurs.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Gliclazide 的其他交互作用
Disopyramide 的其他交互作用
常見問題
Can I take Disopyramide with Gliclazide?
MediHelp rates the interaction as major. Disopyramide and Gliclazide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Disopyramide can cause hypoglycemia, sometimes severe, and may add to the effect of gliclazide. Elderly patients and those with renal impairment are at greater risk.
How serious is the interaction between Disopyramide and Gliclazide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely and reduce the gliclazide dose if needed; consider an alternative antiarrhythmic if recurrent hypoglycemia occurs.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Fluconazole. The full list is on the Gliclazide page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
