藥物交互作用
Glyburide-metformin + Trilaciclib
嚴重程度: 嚴重
Glyburide-metformin and Trilaciclib: major interaction.
最後更新
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摘要
Trilaciclib inhibits OCT2, MATE1 and MATE2-K, so metformin concentrations are expected to increase rather than decrease. This may raise the risk of lactic acidosis, particularly with renal impairment.
用白話說明這項交互作用的意義
Glyburide-metformin and Trilaciclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Glyburide-metformin belongs to Endocrine; Trilaciclib belongs to Oncology.
為什麼會發生
Trilaciclib inhibits OCT2 and MATE transporters, reducing renal clearance of metformin.
處置方式
Avoid metformin on days of trilaciclib where possible, or monitor renal function and lactate-related symptoms closely. Consider a metformin dose reduction.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Glyburide-metformin 的其他交互作用
Trilaciclib 的其他交互作用
常見問題
Can I take Glyburide-metformin with Trilaciclib?
MediHelp rates the interaction as major. Glyburide-metformin and Trilaciclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Trilaciclib inhibits OCT2, MATE1 and MATE2-K, so metformin concentrations are expected to increase rather than decrease. This may raise the risk of lactic acidosis, particularly with renal impairment.
How serious is the interaction between Glyburide-metformin and Trilaciclib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid metformin on days of trilaciclib where possible, or monitor renal function and lactate-related symptoms closely. Consider a metformin dose reduction.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
