藥物交互作用
Cisplatin + Trilaciclib
嚴重程度: 嚴重
Cisplatin and Trilaciclib: major interaction.
最後更新
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摘要
Trilaciclib inhibits renal transporters involved in cisplatin uptake and secretion, which may alter cisplatin accumulation in the kidney. This could increase the risk of dose-related nephrotoxicity.
用白話說明這項交互作用的意義
Cisplatin and Trilaciclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cisplatin belongs to Oncology; Trilaciclib belongs to Oncology.
為什麼會發生
Inhibition of OCT2, MATE1 and MATE2-K by trilaciclib changes renal tubular transport of cisplatin.
處置方式
Avoid using trilaciclib with cisplatin-containing regimens, as labeling advises. If combined, monitor serum creatinine and electrolytes closely.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Cisplatin 的其他交互作用
Trilaciclib 的其他交互作用
常見問題
Can I take Cisplatin with Trilaciclib?
MediHelp rates the interaction as major. Cisplatin and Trilaciclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Trilaciclib inhibits renal transporters involved in cisplatin uptake and secretion, which may alter cisplatin accumulation in the kidney. This could increase the risk of dose-related nephrotoxicity.
How serious is the interaction between Cisplatin and Trilaciclib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using trilaciclib with cisplatin-containing regimens, as labeling advises. If combined, monitor serum creatinine and electrolytes closely.
What other medicines interact with Cisplatin?
MediHelp also lists interactions of Cisplatin with, for example, Cidofovir, Adefovir, Adenovirus types 4 and 7 live. The full list is on the Cisplatin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
