藥物交互作用
Hydrocortisone + Smallpox vaccine live
嚴重程度: 禁忌併用
Hydrocortisone and Smallpox vaccine live: contraindicated interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Live vaccinia vaccine can cause progressive vaccinia and other severe complications in immunocompromised patients. Corticosteroid immunosuppression increases this risk and may reduce vaccine take.
用白話說明這項交互作用的意義
Hydrocortisone and Smallpox vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
為什麼會發生
Corticosteroid-induced immunosuppression allows uncontrolled replication of live vaccinia virus.
處置方式
Avoid in patients on immunosuppressive corticosteroids unless the benefit clearly outweighs risk, such as in post-exposure outbreak settings, and seek specialist advice. Use a non-replicating vaccine if available.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Hydrocortisone 的其他交互作用
常見問題
Can I take Hydrocortisone with Smallpox vaccine live?
MediHelp rates the interaction as contraindicated. Hydrocortisone and Smallpox vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Live vaccinia vaccine can cause progressive vaccinia and other severe complications in immunocompromised patients. Corticosteroid immunosuppression increases this risk and may reduce vaccine take.
How serious is the interaction between Hydrocortisone and Smallpox vaccine live?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid in patients on immunosuppressive corticosteroids unless the benefit clearly outweighs risk, such as in post-exposure outbreak settings, and seek specialist advice. Use a non-replicating vaccine if available.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Adenovirus types 4 and 7 live. The full list is on the Hydrocortisone page.
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