藥物交互作用
Hydrocortisone + Mifepristone
嚴重程度: 禁忌併用
Hydrocortisone and Mifepristone: contraindicated interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Mifepristone blocks the glucocorticoid receptor, so it counteracts hydrocortisone and can precipitate adrenal insufficiency in patients on long-term corticosteroid replacement or treatment. Loss of steroid effect may cause hypotension and hypoglycaemia.
用白話說明這項交互作用的意義
Hydrocortisone and Mifepristone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Hydrocortisone belongs to Endocrine; Mifepristone belongs to Endocrine.
為什麼會發生
Glucocorticoid receptor antagonism opposes hydrocortisone effect
處置方式
Contraindicated with long-term corticosteroid therapy; consider an alternative and do not use mifepristone to treat patients depending on hydrocortisone.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Hydrocortisone 的其他交互作用
Mifepristone 的其他交互作用
常見問題
Can I take Hydrocortisone with Mifepristone?
MediHelp rates the interaction as contraindicated. Hydrocortisone and Mifepristone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Mifepristone blocks the glucocorticoid receptor, so it counteracts hydrocortisone and can precipitate adrenal insufficiency in patients on long-term corticosteroid replacement or treatment. Loss of steroid effect may cause hypotension and hypoglycaemia.
How serious is the interaction between Hydrocortisone and Mifepristone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Contraindicated with long-term corticosteroid therapy; consider an alternative and do not use mifepristone to treat patients depending on hydrocortisone.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Poliovirus vaccine live oral trivalent, Smallpox vaccine live, Adenovirus types 4 and 7 live. The full list is on the Hydrocortisone page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
