藥物交互作用
Hydroxychloroquine + Pimozide
嚴重程度: 禁忌併用
Hydroxychloroquine and Pimozide: contraindicated interaction.
最後更新
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摘要
Pimozide has a marked QT-prolonging effect and hydroxychloroquine adds to this, increasing the chance of torsades de pointes and sudden cardiac death. Pimozide labeling cautions against combination with other QT-prolonging drugs.
用白話說明這項交互作用的意義
Hydroxychloroquine and Pimozide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Hydroxychloroquine belongs to Musculoskeletal; Pimozide belongs to Central Nervous System.
為什麼會發生
Additive QT prolongation via hERG potassium channel blockade.
處置方式
Do not co-administer; select an alternative antimalarial or antirheumatic agent, or a different antipsychotic, in place of one of the two.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Hydroxychloroquine 的其他交互作用
Pimozide 的其他交互作用
常見問題
Can I take Hydroxychloroquine with Pimozide?
MediHelp rates the interaction as contraindicated. Hydroxychloroquine and Pimozide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Pimozide has a marked QT-prolonging effect and hydroxychloroquine adds to this, increasing the chance of torsades de pointes and sudden cardiac death. Pimozide labeling cautions against combination with other QT-prolonging drugs.
How serious is the interaction between Hydroxychloroquine and Pimozide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; select an alternative antimalarial or antirheumatic agent, or a different antipsychotic, in place of one of the two.
What other medicines interact with Hydroxychloroquine?
MediHelp also lists interactions of Hydroxychloroquine with, for example, Arsenic trioxide, Cisapride, Dronedarone. The full list is on the Hydroxychloroquine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
