藥物交互作用
Amisulpride + Pimozide
嚴重程度: 禁忌併用
Amisulpride and Pimozide: contraindicated interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Pimozide and amisulpride each delay ventricular repolarisation, so using them together adds to the chance of marked QTc lengthening. This can precipitate torsades de pointes, particularly with hypokalaemia, bradycardia or structural heart disease.
用白話說明這項交互作用的意義
Amisulpride and Pimozide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Amisulpride belongs to Central Nervous System; Pimozide belongs to Central Nervous System.
為什麼會發生
Additive QTc prolongation through hERG potassium channel blockade
處置方式
Do not co-prescribe; choose an agent without QT liability. If one must continue, obtain ECG and electrolytes first.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pimozide 的其他交互作用
Amisulpride 的其他交互作用
常見問題
Can I take Amisulpride with Pimozide?
MediHelp rates the interaction as contraindicated. Amisulpride and Pimozide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Pimozide and amisulpride each delay ventricular repolarisation, so using them together adds to the chance of marked QTc lengthening. This can precipitate torsades de pointes, particularly with hypokalaemia, bradycardia or structural heart disease.
How serious is the interaction between Amisulpride and Pimozide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-prescribe; choose an agent without QT liability. If one must continue, obtain ECG and electrolytes first.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amitriptyline. The full list is on the Pimozide page.
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