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Imatinib + Lonafarnib

嚴重程度: 禁忌併用

Imatinib and Lonafarnib: contraindicated interaction.

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僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。

本頁的臨床內容僅提供英文版。

摘要

Lonafarnib is a sensitive CYP3A4 substrate, and imatinib inhibits CYP3A4. Increased lonafarnib exposure can worsen gastrointestinal toxicity, hepatic effects, and QT-related risks. Labeling contraindicates strong or moderate CYP3A inhibitors.

用白話說明這項交互作用的意義

Imatinib and Lonafarnib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Imatinib belongs to Oncology; Lonafarnib belongs to Miscellaneous.

證據等級: Moderate

為什麼會發生

Imatinib inhibits CYP3A4 metabolism of lonafarnib, raising its systemic exposure.

處置方式

Avoid the combination. If a CYP3A inhibitor is essential, follow labeling for temporary lonafarnib dose reduction and monitor for toxicity.

可向藥師詢問的問題

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

Pro+ 會員專屬

解鎖完整頁面

建立帳號並開始 Pro+ 試用，即可解鎖 Imatinib 與 Lonafarnib 的完整臨床處置建議、補充說明、證據詳情及整張處方的交互作用檢查工具。

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription
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常見問題

Can I take Imatinib with Lonafarnib?

MediHelp rates the interaction as contraindicated. Imatinib and Lonafarnib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Lonafarnib is a sensitive CYP3A4 substrate, and imatinib inhibits CYP3A4. Increased lonafarnib exposure can worsen gastrointestinal toxicity, hepatic effects, and QT-related risks. Labeling contraindicates strong or moderate CYP3A inhibitors.

How serious is the interaction between Imatinib and Lonafarnib?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination. If a CYP3A inhibitor is essential, follow labeling for temporary lonafarnib dose reduction and monitor for toxicity.

What other medicines interact with Imatinib?

MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Amobarbital, Apalutamide. The full list is on the Imatinib page.

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