藥物交互作用
Imatinib + Ponatinib
嚴重程度: 嚴重
Imatinib and Ponatinib: major interaction.
最後更新
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摘要
Imatinib may increase ponatinib exposure, which carries risks of arterial occlusion, heart failure, hepatotoxicity and pancreatitis. Both are BCR-ABL inhibitors, so the combination is rarely rational.
用白話說明這項交互作用的意義
Imatinib and Ponatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Imatinib belongs to Oncology; Ponatinib belongs to Oncology.
為什麼會發生
Imatinib inhibits CYP3A4, a main route of ponatinib metabolism, and both drugs have overlapping toxicities.
處置方式
Avoid combining the two. If coadministration is unavoidable, monitor for vascular events, liver function and pancreatitis and consider a reduced ponatinib dose.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Imatinib 的其他交互作用
Ponatinib 的其他交互作用
常見問題
Can I take Imatinib with Ponatinib?
MediHelp rates the interaction as major. Imatinib and Ponatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Imatinib may increase ponatinib exposure, which carries risks of arterial occlusion, heart failure, hepatotoxicity and pancreatitis. Both are BCR-ABL inhibitors, so the combination is rarely rational.
How serious is the interaction between Imatinib and Ponatinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining the two. If coadministration is unavoidable, monitor for vascular events, liver function and pancreatitis and consider a reduced ponatinib dose.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
