藥物交互作用
Imipenem / cilastatin + Valacyclovir
嚴重程度: 中度
Imipenem / cilastatin and Valacyclovir: moderate interaction.
最後更新
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摘要
Both drugs can lower the seizure threshold, particularly in renal impairment, so combined use may raise seizure risk. The evidence is limited and largely theoretical.
用白話說明這項交互作用的意義
Imipenem / cilastatin and Valacyclovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
為什麼會發生
Possible additive neurotoxicity; no established mechanism for the combination.
處置方式
Adjust both drugs for renal function and monitor for neurological symptoms. Choose an alternative carbapenem or antiviral in patients with seizure history.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Valacyclovir 的其他交互作用
常見問題
Can I take Imipenem / cilastatin with Valacyclovir?
MediHelp rates the interaction as moderate. Imipenem / cilastatin and Valacyclovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can lower the seizure threshold, particularly in renal impairment, so combined use may raise seizure risk. The evidence is limited and largely theoretical.
How serious is the interaction between Imipenem / cilastatin and Valacyclovir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Adjust both drugs for renal function and monitor for neurological symptoms. Choose an alternative carbapenem or antiviral in patients with seizure history.
What other medicines interact with Valacyclovir?
MediHelp also lists interactions of Valacyclovir with, for example, Talimogene laherparepvec, Bacitracin, Cilastatin-imipenem. The full list is on the Valacyclovir page.
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