藥物交互作用
Talimogene laherparepvec + Valacyclovir
嚴重程度: 嚴重
Talimogene laherparepvec and Valacyclovir: major interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Talimogene laherparepvec is a live attenuated herpes simplex virus that must replicate to be effective. Antiherpetic antivirals may suppress its replication and reduce efficacy.
用白話說明這項交互作用的意義
Talimogene laherparepvec and Valacyclovir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Talimogene laherparepvec belongs to Oncology; Valacyclovir belongs to Anti Virals.
為什麼會發生
Valacyclovir's active form acyclovir inhibits herpes viral DNA polymerase, which may block replication of the oncolytic virus.
處置方式
Avoid antiherpetic agents during talimogene therapy unless needed to treat herpetic infection. Review the need for valacyclovir before each treatment.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Valacyclovir 的其他交互作用
Talimogene laherparepvec 的其他交互作用
常見問題
Can I take Talimogene laherparepvec with Valacyclovir?
MediHelp rates the interaction as major. Talimogene laherparepvec and Valacyclovir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Talimogene laherparepvec is a live attenuated herpes simplex virus that must replicate to be effective. Antiherpetic antivirals may suppress its replication and reduce efficacy.
How serious is the interaction between Talimogene laherparepvec and Valacyclovir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid antiherpetic agents during talimogene therapy unless needed to treat herpetic infection. Review the need for valacyclovir before each treatment.
What other medicines interact with Valacyclovir?
MediHelp also lists interactions of Valacyclovir with, for example, Bacitracin, Cilastatin-imipenem, Elvitegravir / cobicistat / emtricitabine / tenofovir df. The full list is on the Valacyclovir page.
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在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
