藥物交互作用
Mycophenolic acid + Valacyclovir
嚴重程度: 中度
Mycophenolic acid and Valacyclovir: moderate interaction.
最後更新
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摘要
Valacyclovir is converted to acyclovir, which competes with mycophenolate glucuronide for renal tubular secretion. Both may accumulate, particularly with reduced kidney function, raising the risk of neutropenia or neurotoxicity.
用白話說明這項交互作用的意義
Mycophenolic acid and Valacyclovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mycophenolic acid belongs to Miscellaneous; Valacyclovir belongs to Anti Virals.
為什麼會發生
Competition between acyclovir and MPA glucuronide for renal tubular secretion.
處置方式
Monitor complete blood counts and renal function. Reduce doses if cytopenias or renal impairment occur.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Mycophenolic acid 的其他交互作用
Valacyclovir 的其他交互作用
常見問題
Can I take Mycophenolic acid with Valacyclovir?
MediHelp rates the interaction as moderate. Mycophenolic acid and Valacyclovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Valacyclovir is converted to acyclovir, which competes with mycophenolate glucuronide for renal tubular secretion. Both may accumulate, particularly with reduced kidney function, raising the risk of neutropenia or neurotoxicity.
How serious is the interaction between Mycophenolic acid and Valacyclovir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts and renal function. Reduce doses if cytopenias or renal impairment occur.
What other medicines interact with Mycophenolic acid?
MediHelp also lists interactions of Mycophenolic acid with, for example, Activated charcoal, Azathioprine, Cholestyramine. The full list is on the Mycophenolic acid page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
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