藥物交互作用
Isavuconazole + Ritonavir
嚴重程度: 禁忌併用
Isavuconazole and Ritonavir: contraindicated interaction.
最後更新
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摘要
High-dose ritonavir can induce metabolism of isavuconazole and lower its exposure, whereas lower doses act as a CYP3A4 inhibitor and may raise it. The net effect depends on dose and can compromise efficacy or increase toxicity.
用白話說明這項交互作用的意義
Isavuconazole and Ritonavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Isavuconazole belongs to Anti Fungals; Ritonavir belongs to Anti Virals.
為什麼會發生
Dose-dependent mixed CYP3A4 effects of ritonavir; high doses induce isavuconazole clearance.
處置方式
Avoid high-dose ritonavir with isavuconazole. With low-dose boosting, monitor isavuconazole levels, response and adverse effects.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Isavuconazole 的其他交互作用
Ritonavir 的其他交互作用
常見問題
Can I take Isavuconazole with Ritonavir?
MediHelp rates the interaction as contraindicated. Isavuconazole and Ritonavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. High-dose ritonavir can induce metabolism of isavuconazole and lower its exposure, whereas lower doses act as a CYP3A4 inhibitor and may raise it. The net effect depends on dose and can compromise efficacy or increase toxicity.
How serious is the interaction between Isavuconazole and Ritonavir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid high-dose ritonavir with isavuconazole. With low-dose boosting, monitor isavuconazole levels, response and adverse effects.
What other medicines interact with Isavuconazole?
MediHelp also lists interactions of Isavuconazole with, for example, Carbamazepine, Efavirenz, Etravirine. The full list is on the Isavuconazole page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
