藥物交互作用
Efavirenz + Isavuconazole
嚴重程度: 禁忌併用
Efavirenz and Isavuconazole: contraindicated interaction.
最後更新
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摘要
Efavirenz is a moderate CYP3A4 inducer and may lower isavuconazole exposure, compromising antifungal efficacy. Isavuconazole could also alter efavirenz concentrations.
用白話說明這項交互作用的意義
Efavirenz and Isavuconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Efavirenz belongs to Anti Virals; Isavuconazole belongs to Anti Fungals.
為什麼會發生
Efavirenz induces CYP3A4/5, accelerating isavuconazole metabolism.
處置方式
Avoid coadministration and use an alternative antiretroviral such as an integrase inhibitor-based regimen if feasible. If combined, monitor isavuconazole levels and clinical response.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Isavuconazole 的其他交互作用
Efavirenz 的其他交互作用
常見問題
Can I take Efavirenz with Isavuconazole?
MediHelp rates the interaction as contraindicated. Efavirenz and Isavuconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Efavirenz is a moderate CYP3A4 inducer and may lower isavuconazole exposure, compromising antifungal efficacy. Isavuconazole could also alter efavirenz concentrations.
How serious is the interaction between Efavirenz and Isavuconazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration and use an alternative antiretroviral such as an integrase inhibitor-based regimen if feasible. If combined, monitor isavuconazole levels and clinical response.
What other medicines interact with Isavuconazole?
MediHelp also lists interactions of Isavuconazole with, for example, Carbamazepine, Etravirine, Ketoconazole. The full list is on the Isavuconazole page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
