藥物交互作用
Isocarboxazid + Naratriptan
嚴重程度: 嚴重
Isocarboxazid and Naratriptan: major interaction.
最後更新
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摘要
Isocarboxazid irreversibly inhibits monoamine oxidase and naratriptan is a 5-HT1B/1D agonist. Both increase serotonergic or vasoconstrictor tone, so serotonin syndrome or hypertensive effects are possible, although naratriptan is not mainly cleared by MAO.
用白話說明這項交互作用的意義
Isocarboxazid and Naratriptan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Isocarboxazid belongs to Central Nervous System; Naratriptan belongs to Central Nervous System.
為什麼會發生
Additive serotonergic and vasoconstrictor effects
處置方式
Avoid where possible; if used, give naratriptan at the lowest dose and monitor blood pressure and for serotonin toxicity.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Isocarboxazid 的其他交互作用
Naratriptan 的其他交互作用
常見問題
Can I take Isocarboxazid with Naratriptan?
MediHelp rates the interaction as major. Isocarboxazid and Naratriptan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Isocarboxazid irreversibly inhibits monoamine oxidase and naratriptan is a 5-HT1B/1D agonist. Both increase serotonergic or vasoconstrictor tone, so serotonin syndrome or hypertensive effects are possible, although naratriptan is not mainly cleared by MAO.
How serious is the interaction between Isocarboxazid and Naratriptan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid where possible; if used, give naratriptan at the lowest dose and monitor blood pressure and for serotonin toxicity.
What other medicines interact with Isocarboxazid?
MediHelp also lists interactions of Isocarboxazid with, for example, 5-HTP, Amitriptyline, Amobarbital. The full list is on the Isocarboxazid page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
