藥物交互作用
Isocarboxazid + Palonosetron
嚴重程度: 嚴重
Isocarboxazid and Palonosetron: major interaction.
最後更新
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摘要
Non-selective MAO inhibitors markedly raise serotonin availability, and adding a 5-HT3 antagonist has been linked to serotonin syndrome in rare reports. Because the MAOI baseline risk is high, the combination warrants more caution.
用白話說明這項交互作用的意義
Isocarboxazid and Palonosetron can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Isocarboxazid belongs to Central Nervous System; Palonosetron belongs to Gastrointestinal Tract.
為什麼會發生
Irreversible MAO inhibition increases serotonin, with possible additive serotonergic effects from the antiemetic.
處置方式
Prefer a non-serotonergic antiemetic where feasible; if used, give the lowest dose and monitor closely for serotonin syndrome. Stop both drugs and treat if it occurs.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Palonosetron 的其他交互作用
Isocarboxazid 的其他交互作用
常見問題
Can I take Isocarboxazid with Palonosetron?
MediHelp rates the interaction as major. Isocarboxazid and Palonosetron can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Non-selective MAO inhibitors markedly raise serotonin availability, and adding a 5-HT3 antagonist has been linked to serotonin syndrome in rare reports. Because the MAOI baseline risk is high, the combination warrants more caution.
How serious is the interaction between Isocarboxazid and Palonosetron?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-serotonergic antiemetic where feasible; if used, give the lowest dose and monitor closely for serotonin syndrome. Stop both drugs and treat if it occurs.
What other medicines interact with Palonosetron?
MediHelp also lists interactions of Palonosetron with, for example, Apomorphine, Phenelzine, Tranylcypromine. The full list is on the Palonosetron page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
