藥物交互作用
Ixekizumab + Phenytoin
嚴重程度: 輕微
Ixekizumab and Phenytoin: minor interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Chronic inflammation suppresses CYP450 expression, and ixekizumab may reverse this as inflammation is controlled. Clearance of CYP substrates with a narrow therapeutic index such as phenytoin could therefore change when ixekizumab is started or stopped. The clinical effect is expected to be small.
用白話說明這項交互作用的意義
Ixekizumab and Phenytoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ixekizumab belongs to Miscellaneous; Phenytoin belongs to Central Nervous System.
為什麼會發生
Normalisation of cytokine-suppressed CYP450 enzyme expression after IL-17A blockade may alter phenytoin metabolism.
處置方式
Check phenytoin concentrations and clinical response when starting or stopping ixekizumab, and adjust the dose if needed.
可向藥師詢問的問題
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Phenytoin 的其他交互作用
Ixekizumab 的其他交互作用
常見問題
Can I take Ixekizumab with Phenytoin?
MediHelp rates the interaction as minor. Ixekizumab and Phenytoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Chronic inflammation suppresses CYP450 expression, and ixekizumab may reverse this as inflammation is controlled. Clearance of CYP substrates with a narrow therapeutic index such as phenytoin could therefore change when ixekizumab is started or stopped. The clinical effect is expected to be small.
How serious is the interaction between Ixekizumab and Phenytoin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check phenytoin concentrations and clinical response when starting or stopping ixekizumab, and adjust the dose if needed.
What other medicines interact with Phenytoin?
MediHelp also lists interactions of Phenytoin with, for example, Artemether / lumefantrine, Bictegravir, Cabotegravir. The full list is on the Phenytoin page.
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