藥物交互作用
Ketoconazole + Tisotumab vedotin
嚴重程度: 中度
Ketoconazole and Tisotumab vedotin: moderate interaction.
最後更新
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摘要
Ketoconazole may increase exposure to unconjugated MMAE, the cytotoxic payload of tisotumab vedotin, raising the risk of adverse effects such as neuropathy, ocular toxicity and neutropenia.
用白話說明這項交互作用的意義
Ketoconazole and Tisotumab vedotin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ketoconazole belongs to Anti Fungals; Tisotumab vedotin belongs to Oncology.
為什麼會發生
Strong CYP3A4 inhibition reduces MMAE clearance.
處置方式
Monitor closely for adverse reactions during concurrent use, particularly neuropathy and neutropenia.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Ketoconazole 的其他交互作用
Tisotumab vedotin 的其他交互作用
常見問題
Can I take Ketoconazole with Tisotumab vedotin?
MediHelp rates the interaction as moderate. Ketoconazole and Tisotumab vedotin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketoconazole may increase exposure to unconjugated MMAE, the cytotoxic payload of tisotumab vedotin, raising the risk of adverse effects such as neuropathy, ocular toxicity and neutropenia.
How serious is the interaction between Ketoconazole and Tisotumab vedotin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor closely for adverse reactions during concurrent use, particularly neuropathy and neutropenia.
What other medicines interact with Ketoconazole?
MediHelp also lists interactions of Ketoconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Ketoconazole page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
