藥物交互作用
Posaconazole + Tisotumab vedotin
嚴重程度: 中度
Posaconazole and Tisotumab vedotin: moderate interaction.
最後更新
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摘要
The cytotoxic payload of tisotumab vedotin, MMAE, is metabolized by CYP3A4, so a strong inhibitor like posaconazole may increase unconjugated MMAE exposure. This could heighten toxicities such as neutropenia, neuropathy and ocular events.
用白話說明這項交互作用的意義
Posaconazole and Tisotumab vedotin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Posaconazole belongs to Anti Fungals; Tisotumab vedotin belongs to Oncology.
為什麼會發生
Strong CYP3A4 inhibition by posaconazole reduces the clearance of released MMAE.
處置方式
Monitor closely for signs of MMAE toxicity, including blood counts and neuropathy, during concomitant use. Consider an alternative antifungal where feasible.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Posaconazole 的其他交互作用
Tisotumab vedotin 的其他交互作用
常見問題
Can I take Posaconazole with Tisotumab vedotin?
MediHelp rates the interaction as moderate. Posaconazole and Tisotumab vedotin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The cytotoxic payload of tisotumab vedotin, MMAE, is metabolized by CYP3A4, so a strong inhibitor like posaconazole may increase unconjugated MMAE exposure. This could heighten toxicities such as neutropenia, neuropathy and ocular events.
How serious is the interaction between Posaconazole and Tisotumab vedotin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor closely for signs of MMAE toxicity, including blood counts and neuropathy, during concomitant use. Consider an alternative antifungal where feasible.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
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