藥物交互作用

Clarithromycin + Tisotumab vedotin

嚴重程度: 中度

Clarithromycin and Tisotumab vedotin: moderate interaction.

最後更新 13 十月 2026

僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。

本頁的臨床內容僅提供英文版。

摘要

The cytotoxic payload MMAE from tisotumab vedotin is a CYP3A4 substrate. A strong inhibitor like clarithromycin may raise MMAE exposure and increase toxicity, including neuropathy, neutropenia and ocular effects.

用白話說明這項交互作用的意義

Clarithromycin and Tisotumab vedotin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Clarithromycin belongs to Anti Bacterial; Tisotumab vedotin belongs to Oncology.

證據等級: Moderate

為什麼會發生

Clarithromycin inhibits CYP3A4 metabolism of MMAE.

處置方式

Consider a non-CYP3A4-inhibiting antibiotic. If combined, monitor for adverse reactions of tisotumab vedotin.

可向藥師詢問的問題

Should I take them at different times of day?
Does the dose of either medicine need to change?
Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

Pro+ 會員專屬

解鎖完整頁面

建立帳號並開始 Pro+ 試用，即可解鎖 Clarithromycin 與 Tisotumab vedotin 的完整臨床處置建議、補充說明、證據詳情及整張處方的交互作用檢查工具。

Full clinical management advice
Additional notes
Evidence detail
Interaction checker for a whole prescription

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常見問題

Can I take Clarithromycin with Tisotumab vedotin?

MediHelp rates the interaction as moderate. Clarithromycin and Tisotumab vedotin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The cytotoxic payload MMAE from tisotumab vedotin is a CYP3A4 substrate. A strong inhibitor like clarithromycin may raise MMAE exposure and increase toxicity, including neuropathy, neutropenia and ocular effects.

How serious is the interaction between Clarithromycin and Tisotumab vedotin?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a non-CYP3A4-inhibiting antibiotic. If combined, monitor for adverse reactions of tisotumab vedotin.

What other medicines interact with Clarithromycin?

MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.

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摘要