藥物交互作用
Lorlatinib + Pralsetinib
嚴重程度: 嚴重
Lorlatinib and Pralsetinib: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Pralsetinib is cleared by CYP3A4, and lorlatinib induces CYP3A. Lower pralsetinib concentrations may reduce antitumor efficacy in RET-driven cancers.
用白話說明這項交互作用的意義
Lorlatinib and Pralsetinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Lorlatinib belongs to Oncology; Pralsetinib belongs to Oncology.
為什麼會發生
Lorlatinib induces CYP3A4, increasing pralsetinib metabolism.
處置方式
Avoid combining; if unavoidable, adjust pralsetinib dose per labeling for CYP3A inducers and monitor tumor response.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Lorlatinib 的其他交互作用
Pralsetinib 的其他交互作用
常見問題
Can I take Lorlatinib with Pralsetinib?
MediHelp rates the interaction as major. Lorlatinib and Pralsetinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pralsetinib is cleared by CYP3A4, and lorlatinib induces CYP3A. Lower pralsetinib concentrations may reduce antitumor efficacy in RET-driven cancers.
How serious is the interaction between Lorlatinib and Pralsetinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining; if unavoidable, adjust pralsetinib dose per labeling for CYP3A inducers and monitor tumor response.
What other medicines interact with Lorlatinib?
MediHelp also lists interactions of Lorlatinib with, for example, Amobarbital, Apalutamide, Butabarbital. The full list is on the Lorlatinib page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
