藥物交互作用
Lurasidone + Primidone
嚴重程度: 禁忌併用
Lurasidone and Primidone: contraindicated interaction.
最後更新
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摘要
Primidone is metabolized to phenobarbital, which induces CYP3A4 and may reduce lurasidone concentrations. This can lead to inadequate antipsychotic effect and relapse. Strong CYP3A4 inducers are contraindicated with lurasidone.
用白話說明這項交互作用的意義
Lurasidone and Primidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Lurasidone belongs to Central Nervous System; Primidone belongs to Central Nervous System.
為什麼會發生
Induction of CYP3A4 by primidone and its phenobarbital metabolite increases lurasidone clearance.
處置方式
Avoid the combination; consider a non-inducing anticonvulsant or an alternative antipsychotic and monitor symptom control.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Lurasidone 的其他交互作用
Primidone 的其他交互作用
常見問題
Can I take Lurasidone with Primidone?
MediHelp rates the interaction as contraindicated. Lurasidone and Primidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Primidone is metabolized to phenobarbital, which induces CYP3A4 and may reduce lurasidone concentrations. This can lead to inadequate antipsychotic effect and relapse. Strong CYP3A4 inducers are contraindicated with lurasidone.
How serious is the interaction between Lurasidone and Primidone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; consider a non-inducing anticonvulsant or an alternative antipsychotic and monitor symptom control.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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