藥物交互作用
Meperidine + Procarbazine
嚴重程度: 禁忌併用
Meperidine and Procarbazine: contraindicated interaction.
最後更新
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摘要
Procarbazine has MAO-inhibiting properties, and meperidine with MAO inhibitors can cause severe, sometimes fatal serotonin syndrome or excitatory reactions with hyperthermia. Meperidine is the opioid most associated with this reaction.
用白話說明這項交互作用的意義
Meperidine and Procarbazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Meperidine belongs to Musculoskeletal; Procarbazine belongs to Oncology.
為什麼會發生
MAO inhibition combined with meperidine's serotonin reuptake inhibition leading to serotonin excess.
處置方式
Do not use together or within 14 days of stopping an MAO inhibitor. Choose a non-serotonergic analgesic such as morphine, with monitoring.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Meperidine 的其他交互作用
Procarbazine 的其他交互作用
常見問題
Can I take Meperidine with Procarbazine?
MediHelp rates the interaction as contraindicated. Meperidine and Procarbazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Procarbazine has MAO-inhibiting properties, and meperidine with MAO inhibitors can cause severe, sometimes fatal serotonin syndrome or excitatory reactions with hyperthermia. Meperidine is the opioid most associated with this reaction.
How serious is the interaction between Meperidine and Procarbazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together or within 14 days of stopping an MAO inhibitor. Choose a non-serotonergic analgesic such as morphine, with monitoring.
What other medicines interact with Meperidine?
MediHelp also lists interactions of Meperidine with, for example, Alvimopan, Isocarboxazid, Methylene blue. The full list is on the Meperidine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
