藥物交互作用
Isocarboxazid + Meperidine
嚴重程度: 禁忌併用
Isocarboxazid and Meperidine: contraindicated interaction.
最後更新
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摘要
Meperidine blocks neuronal serotonin reuptake and, with isocarboxazid, can cause a severe reaction with agitation, hyperthermia, rigidity and sometimes coma or death. The reaction is both serotonergic and, in some cases, hypertensive.
用白話說明這項交互作用的意義
Isocarboxazid and Meperidine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Isocarboxazid belongs to Central Nervous System; Meperidine belongs to Musculoskeletal.
為什麼會發生
Serotonergic toxicity (MAO inhibition plus serotonin reuptake block by meperidine)
處置方式
Contraindicated; do not use meperidine within 14 days of an MAO inhibitor and select a non-serotonergic opioid such as morphine with caution.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Meperidine 的其他交互作用
Isocarboxazid 的其他交互作用
常見問題
Can I take Isocarboxazid with Meperidine?
MediHelp rates the interaction as contraindicated. Isocarboxazid and Meperidine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Meperidine blocks neuronal serotonin reuptake and, with isocarboxazid, can cause a severe reaction with agitation, hyperthermia, rigidity and sometimes coma or death. The reaction is both serotonergic and, in some cases, hypertensive.
How serious is the interaction between Isocarboxazid and Meperidine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Contraindicated; do not use meperidine within 14 days of an MAO inhibitor and select a non-serotonergic opioid such as morphine with caution.
What other medicines interact with Meperidine?
MediHelp also lists interactions of Meperidine with, for example, Alvimopan, Methylene blue, Olanzapine / samidorphan. The full list is on the Meperidine page.
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