藥物交互作用
Metformin + Trilaciclib
嚴重程度: 嚴重
Metformin and Trilaciclib: major interaction.
最後更新
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摘要
Trilaciclib inhibits renal transporters involved in metformin elimination and can raise metformin exposure. This increases the risk of metformin toxicity, including lactic acidosis.
用白話說明這項交互作用的意義
Metformin and Trilaciclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Metformin belongs to Endocrine; Trilaciclib belongs to Oncology.
為什麼會發生
Trilaciclib inhibits OCT2, MATE1 and MATE2-K, decreasing renal secretion of metformin.
處置方式
Avoid metformin on the days of trilaciclib administration if possible, or monitor closely for lactic acidosis and adjust metformin dose. Check renal function beforehand.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Metformin 的其他交互作用
Trilaciclib 的其他交互作用
常見問題
Can I take Metformin with Trilaciclib?
MediHelp rates the interaction as major. Metformin and Trilaciclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Trilaciclib inhibits renal transporters involved in metformin elimination and can raise metformin exposure. This increases the risk of metformin toxicity, including lactic acidosis.
How serious is the interaction between Metformin and Trilaciclib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid metformin on the days of trilaciclib administration if possible, or monitor closely for lactic acidosis and adjust metformin dose. Check renal function beforehand.
What other medicines interact with Metformin?
MediHelp also lists interactions of Metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
