藥物交互作用
Methyldopa + Tranylcypromine
嚴重程度: 禁忌併用
Methyldopa and Tranylcypromine: contraindicated interaction.
最後更新
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摘要
MAO inhibitors are listed as contraindicated with methyldopa in labeling because of the risk of hypertensive reactions and excitation, and tranylcypromine may also oppose the hypotensive effect. Methyldopa is metabolised to catecholamine-like compounds that can be potentiated when MAO is inhibited.
用白話說明這項交互作用的意義
Methyldopa and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Methyldopa belongs to Cardiovascular; Tranylcypromine belongs to Central Nervous System.
為什麼會發生
MAO inhibition prevents breakdown of methyldopa-derived catecholamine metabolites, causing excess adrenergic stimulation.
處置方式
Do not combine. Allow an adequate washout, about 14 days after stopping the MAOI, before starting methyldopa, and choose another antihypertensive.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Methyldopa 的其他交互作用
Tranylcypromine 的其他交互作用
常見問題
Can I take Methyldopa with Tranylcypromine?
MediHelp rates the interaction as contraindicated. Methyldopa and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. MAO inhibitors are listed as contraindicated with methyldopa in labeling because of the risk of hypertensive reactions and excitation, and tranylcypromine may also oppose the hypotensive effect. Methyldopa is metabolised to catecholamine-like compounds that can be potentiated when MAO is inhibited.
How serious is the interaction between Methyldopa and Tranylcypromine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine. Allow an adequate washout, about 14 days after stopping the MAOI, before starting methyldopa, and choose another antihypertensive.
What other medicines interact with Methyldopa?
MediHelp also lists interactions of Methyldopa with, for example, Iobenguane i, Lofexidine, Pexidartinib. The full list is on the Methyldopa page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
