藥品參考
Methyldopa
Methyldopa is a medicine in the class cardiovascular. It is used for hypertension.
- 藥物類別: Cardiovascular
- 用途: hypertension
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
重點資訊
- 藥物類別
- Cardiovascular
- 常見劑型
- 錠劑
- 常見規格
- 250 mg, 500 mg
- 已知交互作用
- 92 (禁忌併用: 1 · 嚴重: 5 · 中度: 82 · 輕微: 4)
- 商品名
- 15
- 國家與市場
- 4
用途
作用方式
Methyldopa may lower blood pressure by stimulating central inhibitory alpha-adrenergic receptors, false neurotransmission, and/or reduction of plasma renin activity.
成人常用劑量（仿單摘要）
Hypertension (Initial): 250 mg PO q8-12hr for 2 days, increase q2Days PRN
懷孕與哺乳
- 懷孕
- Safe Decades of use in all trimesters without fetal harm; treated hypertensive pregnancies had better outcomes. Starting at 16 to 20 weeks was linked to a slightly smaller head size, with no effects at follow-up. An option for high blood pressure in pregnancy; NICE prefers labetalol, then nifedipine.
- 哺乳
- Safe Passes into milk in small amounts that are not expected to affect the infant; LactMed: no special precautions. US label: use with caution. NICE advises stopping methyldopa within 2 days after the birth and changing to another antihypertensive.
已通報的副作用
- Dizziness
- Bradycardia
- Angina
- Orthostatic hypotension
- Depression
- Lethargy
禁忌症
- Active liver disease, liver disorders associated with previous methyldopa treatment
- Hypersensitivity to methyldopa or other ingredients (eg, sulfites)
- Pheochromocytoma
哪些人需要特別留意
- May impair ability to perform hazardous tasks
- Interferes with some lab tests
- IM/SC NOT recommended due to erratic absorption
請告知藥師或醫師您是否懷孕或哺乳、是否患有腎臟或肝臟疾病、是否有過敏，以及您正在使用的所有其他藥物或保健品。
重要交互作用 (92)
- Methyldopa + Tranylcypromine Contraindicated
- Iobenguane i + Methyldopa Major
- Lofexidine + Methyldopa Major
- Methyldopa + Pexidartinib Major
- Methyldopa + Pretomanid Major
- Methyldopa + Thioridazine Major
- Adrenaline-articaine + Methyldopa Moderate
- Apomorphine + Methyldopa Moderate
- Aripiprazole + Methyldopa Moderate
- Benperidol + Methyldopa Moderate
Pro+ 會員專屬
解鎖完整頁面
建立帳號並開始 Pro+ 試用，即可開啟 Methyldopa 的完整藥品專論：劑量、懷孕與哺乳、副作用、警示及所有交互作用。
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
- IV preparation and dilution
在網頁版免費試用 Pro+ 14 天，無需信用卡。
同類別的其他藥品
常見問題
What is Methyldopa used for?
Methyldopa is a medicine in the class cardiovascular. It is used for Hypertension.
What side effects have been reported with Methyldopa?
Dizziness, Bradycardia, Angina, Orthostatic hypotension, Depression, Lethargy.
Can Methyldopa be taken in pregnancy or while breastfeeding?
Pregnancy: Safe. Decades of use in all trimesters without fetal harm; treated hypertensive pregnancies had better outcomes. Starting at 16 to 20 weeks was linked to a slightly smaller head size, with no effects at follow-up. An option for high blood pressure in pregnancy; NICE prefers labetalol, then nifedipine. Breastfeeding: Safe. Passes into milk in small amounts that are not expected to affect the infant; LactMed: no special precautions. US label: use with caution. NICE advises stopping methyldopa within 2 days after the birth and changing to another antihypertensive.
What does Methyldopa interact with?
MediHelp lists 92 known interactions for Methyldopa. Contraindicated: 1 · Major: 5 · Moderate: 82 · Minor: 4. The most serious include Tranylcypromine, Iobenguane i, Lofexidine.
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