藥物交互作用
Lofexidine + Methyldopa
嚴重程度: 嚴重
Lofexidine and Methyldopa: major interaction.
最後更新
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摘要
Lofexidine is a central alpha-2 agonist that lowers blood pressure and heart rate, and methyldopa acts through a similar central pathway. Together they can cause excessive hypotension and bradycardia.
用白話說明這項交互作用的意義
Lofexidine and Methyldopa can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Lofexidine belongs to Central Nervous System; Methyldopa belongs to Cardiovascular.
為什麼會發生
Additive central sympatholytic effects reducing blood pressure and heart rate.
處置方式
Avoid the combination where possible, or monitor blood pressure and pulse closely and reduce doses if hypotension or bradycardia develops.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Methyldopa 的其他交互作用
Lofexidine 的其他交互作用
常見問題
Can I take Lofexidine with Methyldopa?
MediHelp rates the interaction as major. Lofexidine and Methyldopa can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lofexidine is a central alpha-2 agonist that lowers blood pressure and heart rate, and methyldopa acts through a similar central pathway. Together they can cause excessive hypotension and bradycardia.
How serious is the interaction between Lofexidine and Methyldopa?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, or monitor blood pressure and pulse closely and reduce doses if hypotension or bradycardia develops.
What other medicines interact with Methyldopa?
MediHelp also lists interactions of Methyldopa with, for example, Tranylcypromine, Iobenguane i, Pexidartinib. The full list is on the Methyldopa page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
