藥物交互作用
Modafinil + Nirogacestat
嚴重程度: 嚴重
Modafinil and Nirogacestat: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Modafinil may reduce nirogacestat exposure and therefore its efficacy in desmoid tumors. Labeling advises avoiding moderate CYP3A inducers.
用白話說明這項交互作用的意義
Modafinil and Nirogacestat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Modafinil belongs to Central Nervous System; Nirogacestat belongs to Oncology.
為什麼會發生
Modafinil induces CYP3A4, increasing nirogacestat clearance.
處置方式
Avoid the combination and use a non-inducing alternative where possible. If used together, monitor tumor response.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Modafinil 的其他交互作用
Nirogacestat 的其他交互作用
常見問題
Can I take Modafinil with Nirogacestat?
MediHelp rates the interaction as major. Modafinil and Nirogacestat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Modafinil may reduce nirogacestat exposure and therefore its efficacy in desmoid tumors. Labeling advises avoiding moderate CYP3A inducers.
How serious is the interaction between Modafinil and Nirogacestat?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a non-inducing alternative where possible. If used together, monitor tumor response.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lorlatinib. The full list is on the Modafinil page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
