藥物交互作用
Lorlatinib + Modafinil
嚴重程度: 嚴重
Lorlatinib and Modafinil: major interaction.
最後更新
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摘要
Modafinil is a weak to moderate CYP3A4 inducer and may lower lorlatinib concentrations, reducing antitumor efficacy. Lorlatinib labeling warns that CYP3A inducers can increase hepatotoxicity risk, notably with strong inducers.
用白話說明這項交互作用的意義
Lorlatinib and Modafinil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Lorlatinib belongs to Oncology; Modafinil belongs to Central Nervous System.
為什麼會發生
Modafinil induces CYP3A4, increasing the metabolism of lorlatinib, a CYP3A4 substrate.
處置方式
Avoid the combination where possible and choose a non-inducing alternative. If it cannot be avoided, monitor liver enzymes, bilirubin and tumor response.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Modafinil 的其他交互作用
Lorlatinib 的其他交互作用
常見問題
Can I take Lorlatinib with Modafinil?
MediHelp rates the interaction as major. Lorlatinib and Modafinil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Modafinil is a weak to moderate CYP3A4 inducer and may lower lorlatinib concentrations, reducing antitumor efficacy. Lorlatinib labeling warns that CYP3A inducers can increase hepatotoxicity risk, notably with strong inducers.
How serious is the interaction between Lorlatinib and Modafinil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and choose a non-inducing alternative. If it cannot be avoided, monitor liver enzymes, bilirubin and tumor response.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lumateperone. The full list is on the Modafinil page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
