藥物交互作用
Mavacamten + Modafinil
嚴重程度: 嚴重
Mavacamten and Modafinil: major interaction.
最後更新
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摘要
Mavacamten is cleared mainly by CYP2C19 with CYP3A4 contribution, and exposure changes can cause loss of efficacy or excessive negative inotropy leading to systolic heart failure. Modafinil has mixed effects, inducing CYP3A4 and inhibiting CYP2C19, making the net exposure unpredictable.
用白話說明這項交互作用的意義
Mavacamten and Modafinil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Mavacamten belongs to Cardiovascular; Modafinil belongs to Central Nervous System.
為什麼會發生
Modafinil inhibits CYP2C19 and induces CYP3A4, altering mavacamten metabolism in opposing directions.
處置方式
Avoid the combination where possible; if used, monitor LVEF and clinical status closely and adjust mavacamten dose by echocardiographic guidance.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Modafinil 的其他交互作用
Mavacamten 的其他交互作用
常見問題
Can I take Mavacamten with Modafinil?
MediHelp rates the interaction as major. Mavacamten and Modafinil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mavacamten is cleared mainly by CYP2C19 with CYP3A4 contribution, and exposure changes can cause loss of efficacy or excessive negative inotropy leading to systolic heart failure. Modafinil has mixed effects, inducing CYP3A4 and inhibiting CYP2C19, making the net exposure unpredictable.
How serious is the interaction between Mavacamten and Modafinil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if used, monitor LVEF and clinical status closely and adjust mavacamten dose by echocardiographic guidance.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lorlatinib. The full list is on the Modafinil page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
