藥物交互作用
Nitroglycerin rectal + Tadalafil
嚴重程度: 禁忌併用
Nitroglycerin rectal and Tadalafil: contraindicated interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Tadalafil markedly enhances the blood pressure lowering effect of rectal nitroglycerin. Severe hypotension may occur and the risk lasts well beyond the dose because of tadalafil's long half-life.
用白話說明這項交互作用的意義
Nitroglycerin rectal and Tadalafil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
為什麼會發生
Additive cGMP-mediated vasodilation from nitric oxide donation and PDE5 inhibition.
處置方式
Avoid combination; keep nitrates at least 48 hours away from tadalafil. Use non-nitrate therapy within that window.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Tadalafil 的其他交互作用
常見問題
Can I take Nitroglycerin rectal with Tadalafil?
MediHelp rates the interaction as contraindicated. Nitroglycerin rectal and Tadalafil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Tadalafil markedly enhances the blood pressure lowering effect of rectal nitroglycerin. Severe hypotension may occur and the risk lasts well beyond the dose because of tadalafil's long half-life.
How serious is the interaction between Nitroglycerin rectal and Tadalafil?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combination; keep nitrates at least 48 hours away from tadalafil. Use non-nitrate therapy within that window.
What other medicines interact with Tadalafil?
MediHelp also lists interactions of Tadalafil with, for example, Amyl nitrite, Isosorbide dinitrate, Isosorbide mononitrate. The full list is on the Tadalafil page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
