藥物交互作用
Nitroglycerin transdermal + Tadalafil
嚴重程度: 禁忌併用
Nitroglycerin transdermal and Tadalafil: contraindicated interaction.
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摘要
Tadalafil greatly amplifies the vasodilator effect of nitroglycerin patches, which deliver nitrate continuously. This can cause severe hypotension, syncope and cardiac ischemia.
用白話說明這項交互作用的意義
Nitroglycerin transdermal and Tadalafil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
為什麼會發生
Nitric oxide donation increases cGMP and tadalafil inhibits PDE5-mediated cGMP degradation, causing additive vasodilation.
處置方式
Avoid the combination; remove the patch and do not give nitrates within 48 hours of tadalafil. Use a non-nitrate antianginal if the patient needs ongoing tadalafil.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Tadalafil 的其他交互作用
常見問題
Can I take Nitroglycerin transdermal with Tadalafil?
MediHelp rates the interaction as contraindicated. Nitroglycerin transdermal and Tadalafil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Tadalafil greatly amplifies the vasodilator effect of nitroglycerin patches, which deliver nitrate continuously. This can cause severe hypotension, syncope and cardiac ischemia.
How serious is the interaction between Nitroglycerin transdermal and Tadalafil?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; remove the patch and do not give nitrates within 48 hours of tadalafil. Use a non-nitrate antianginal if the patient needs ongoing tadalafil.
What other medicines interact with Tadalafil?
MediHelp also lists interactions of Tadalafil with, for example, Amyl nitrite, Isosorbide dinitrate, Isosorbide mononitrate. The full list is on the Tadalafil page.
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