藥物交互作用
Isosorbide mononitrate + Tadalafil
嚴重程度: 禁忌併用
Isosorbide mononitrate and Tadalafil: contraindicated interaction.
最後更新 來源: US FDA label
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Tadalafil markedly potentiates the hypotensive effect of nitrates, which can cause severe, potentially life-threatening hypotension, syncope or myocardial ischaemia. The effect persists for a prolonged period because of tadalafil's long half-life. Nitrates in any form are contraindicated with tadalafil.
用白話說明這項交互作用的意義
Isosorbide mononitrate and Tadalafil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Isosorbide mononitrate belongs to Cardiovascular; Tadalafil belongs to Genitourinary.
為什麼會發生
Nitrates increase cGMP by nitric oxide release while tadalafil inhibits PDE5-mediated cGMP breakdown, causing excessive vasodilation.
處置方式
Do not coadminister. Nitrates should not be given within at least 48 hours after tadalafil, and in emergencies the decision should be under close medical supervision.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
參考資料
- Cialis (tadalafil) Prescribing Information - Contraindications — FDA Label
- Cialis SmPC - Contraindications — EMA SmPC
Tadalafil 的其他交互作用
Isosorbide mononitrate 的其他交互作用
常見問題
Can I take Isosorbide mononitrate with Tadalafil?
MediHelp rates the interaction as contraindicated. Isosorbide mononitrate and Tadalafil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Tadalafil markedly potentiates the hypotensive effect of nitrates, which can cause severe, potentially life-threatening hypotension, syncope or myocardial ischaemia. The effect persists for a prolonged period because of tadalafil's long half-life. Nitrates in any form are contraindicated with tadalafil.
How serious is the interaction between Isosorbide mononitrate and Tadalafil?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister. Nitrates should not be given within at least 48 hours after tadalafil, and in emergencies the decision should be under close medical supervision.
What other medicines interact with Tadalafil?
MediHelp also lists interactions of Tadalafil with, for example, Amyl nitrite, Isosorbide dinitrate, Nitroglycerin po. The full list is on the Tadalafil page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
