藥物交互作用
Ombitasvir / paritaprevir / ritonavir and dasabuvir + Pitavastatin
嚴重程度: 嚴重
Ombitasvir / paritaprevir / ritonavir and dasabuvir and Pitavastatin: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Paritaprevir inhibits OATP1B1/1B3 and can raise exposure to statins. Higher pitavastatin levels increase the risk of myopathy, and the labeling of the combination advises against pitavastatin use.
用白話說明這項交互作用的意義
Ombitasvir / paritaprevir / ritonavir and dasabuvir and Pitavastatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
為什麼會發生
Paritaprevir inhibits OATP1B1/1B3 hepatic uptake of pitavastatin.
處置方式
Avoid the combination if possible and hold pitavastatin during the antiviral course, or switch to a statin with a defined dose limit. Monitor for myopathy if coadministered.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pitavastatin 的其他交互作用
常見問題
Can I take Ombitasvir / paritaprevir / ritonavir and dasabuvir with Pitavastatin?
MediHelp rates the interaction as major. Ombitasvir / paritaprevir / ritonavir and dasabuvir and Pitavastatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Paritaprevir inhibits OATP1B1/1B3 and can raise exposure to statins. Higher pitavastatin levels increase the risk of myopathy, and the labeling of the combination advises against pitavastatin use.
How serious is the interaction between Ombitasvir / paritaprevir / ritonavir and dasabuvir and Pitavastatin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible and hold pitavastatin during the antiviral course, or switch to a statin with a defined dose limit. Monitor for myopathy if coadministered.
What other medicines interact with Pitavastatin?
MediHelp also lists interactions of Pitavastatin with, for example, Cyclosporin, Erythromycin base, Erythromycin ethylsuccinate. The full list is on the Pitavastatin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
