藥物交互作用
Ondansetron + Thioridazine
嚴重程度: 禁忌併用
Ondansetron and Thioridazine: contraindicated interaction.
最後更新
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摘要
Thioridazine causes marked dose-related QT prolongation and is contraindicated with other drugs that prolong the QT interval. Adding ondansetron further increases the risk of torsades de pointes and sudden cardiac death.
用白話說明這項交互作用的意義
Ondansetron and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ondansetron belongs to Gastrointestinal Tract; Thioridazine belongs to Central Nervous System.
為什麼會發生
Additive QT prolongation through blockade of cardiac potassium channels.
處置方式
Avoid the combination and choose an antiemetic with less QT effect, such as one without 5-HT3 antagonism, with ECG review. If unavoidable, correct electrolytes and monitor the ECG continuously.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Ondansetron 的其他交互作用
Thioridazine 的其他交互作用
常見問題
Can I take Ondansetron with Thioridazine?
MediHelp rates the interaction as contraindicated. Ondansetron and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Thioridazine causes marked dose-related QT prolongation and is contraindicated with other drugs that prolong the QT interval. Adding ondansetron further increases the risk of torsades de pointes and sudden cardiac death.
How serious is the interaction between Ondansetron and Thioridazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose an antiemetic with less QT effect, such as one without 5-HT3 antagonism, with ECG review. If unavoidable, correct electrolytes and monitor the ECG continuously.
What other medicines interact with Ondansetron?
MediHelp also lists interactions of Ondansetron with, for example, Apomorphine, Vandetanib, Adagrasib. The full list is on the Ondansetron page.
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