藥物交互作用
Phenytoin + Roflumilast
嚴重程度: 嚴重
Phenytoin and Roflumilast: major interaction.
最後更新 來源: US FDA label
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摘要
Phenytoin is a strong inducer of CYP enzymes and can substantially lower roflumilast and active metabolite exposure. Roflumilast labeling advises against use with strong inducers because efficacy may be lost.
用白話說明這項交互作用的意義
Phenytoin and Roflumilast can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Phenytoin belongs to Central Nervous System; Roflumilast belongs to Respiratory.
為什麼會發生
Induction of CYP3A4 and CYP1A2 by phenytoin increases roflumilast metabolism.
處置方式
Avoid the combination and consider an alternative COPD therapy. If both are continued, monitor exacerbation frequency closely.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
參考資料
- Roflumilast - FDA drug label (DailyMed) — openFDA / DailyMed
Roflumilast 的其他交互作用
Phenytoin 的其他交互作用
常見問題
Can I take Phenytoin with Roflumilast?
MediHelp rates the interaction as major. Phenytoin and Roflumilast can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Phenytoin is a strong inducer of CYP enzymes and can substantially lower roflumilast and active metabolite exposure. Roflumilast labeling advises against use with strong inducers because efficacy may be lost.
How serious is the interaction between Phenytoin and Roflumilast?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and consider an alternative COPD therapy. If both are continued, monitor exacerbation frequency closely.
What other medicines interact with Roflumilast?
MediHelp also lists interactions of Roflumilast with, for example, Apalutamide, Carbamazepine, Efavirenz. The full list is on the Roflumilast page.
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