藥物交互作用
Fosphenytoin + Roflumilast
嚴重程度: 嚴重
Fosphenytoin and Roflumilast: major interaction.
最後更新 來源: UK SmPC
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摘要
Fosphenytoin is converted to phenytoin, which induces CYP3A4 and CYP1A2 and substantially reduces roflumilast exposure. Therapeutic effect may be lost.
用白話說明這項交互作用的意義
Fosphenytoin and Roflumilast can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fosphenytoin belongs to Central Nervous System; Roflumilast belongs to Respiratory.
為什麼會發生
Phenytoin induces CYP3A4 and CYP1A2, increasing roflumilast clearance.
處置方式
Avoid the combination where possible, as the label advises against strong inducers. If both are required, monitor COPD control closely and consider an alternative to roflumilast.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
參考資料
- DAXAS 250 micrograms tablets - SmPC sections 4.3/4.5 (class statement: strong cytochrome P450 enzyme inducers; "the use of strong cytochrome P450 enzyme inducers (e.g. phenobarbital, carbamazepine, phenytoin) may reduce the therapeutic efficacy of roflumilast") — electronic medicines compendium (UK SmPC)
Roflumilast 的其他交互作用
Fosphenytoin 的其他交互作用
常見問題
Can I take Fosphenytoin with Roflumilast?
MediHelp rates the interaction as major. Fosphenytoin and Roflumilast can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fosphenytoin is converted to phenytoin, which induces CYP3A4 and CYP1A2 and substantially reduces roflumilast exposure. Therapeutic effect may be lost.
How serious is the interaction between Fosphenytoin and Roflumilast?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, as the label advises against strong inducers. If both are required, monitor COPD control closely and consider an alternative to roflumilast.
What other medicines interact with Roflumilast?
MediHelp also lists interactions of Roflumilast with, for example, Apalutamide, Carbamazepine, Efavirenz. The full list is on the Roflumilast page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
