藥品參考
Roflumilast
Roflumilast is a medicine in the class respiratory. It is used for copd.
- 藥物類別: Respiratory
- 用途: copd
最後更新 來源: US FDA label, EMA SmPC, Health Canada product monograph
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
重點資訊
- 藥物類別
- Respiratory
- ATC 代碼
- R03DX07
- 常見劑型
- 錠劑, 乳膏, 吸入器
- 常見規格
- 500 mcg, 0.5 mg
- 已知交互作用
- 64 (嚴重: 12 · 中度: 41 · 輕微: 11)
- 商品名
- 10
- 國家與市場
- 5
用途
作用方式
Roflumilast is a phosphodiesterase-4 (PDE-4) inhibitor which, due to its selective inhibition of the PDE4 isoenzyme, has potential antiinflammatory and antimodulatory effects in the pulmonary system.
成人常用劑量（仿單摘要）
COPD: 500 mcg orally once every Day.
懷孕與哺乳
- 懷孕
- Unknown No adequate human data. No malformations in rats or rabbits; pregnancy loss, stillbirth and poorer pup survival at 10 to 49 times the human dose, and it disrupted labour in mice. EU label: not recommended in pregnancy; US: do not use during labour and delivery.
- 哺乳
- Unknown No human data; it passes into rat milk. US and EU labels: should not be used while breastfeeding. LactMed: over 97% protein bound, so milk levels are probably very low, but the oral drug is best avoided. Cream: use on small areas only, not on the breast.
已通報的副作用
- Headache
- Diarrhea
- Nausea
- Weight loss
禁忌症
- Hypersensitivity
- Moderate-to-severe liver impairment (Child-Pugh class B or C)
哪些人需要特別留意
- You should not use roflumilast if you have moderate or severe liver disease.
- You may take roflumilast with or without food.
請告知藥師或醫師您是否懷孕或哺乳、是否患有腎臟或肝臟疾病、是否有過敏，以及您正在使用的所有其他藥物或保健品。
重要交互作用 (64)
- Apalutamide + Roflumilast Major
- Carbamazepine + Roflumilast Major
- Efavirenz + Roflumilast Major
- Enzalutamide + Roflumilast Major
- Fosphenytoin + Roflumilast Major
- Pentobarbital + Roflumilast Major
- Phenobarbital + Roflumilast Major
- Phenytoin + Roflumilast Major
- Primidone + Roflumilast Major
- Rifampin + Roflumilast Major
Pro+ 會員專屬
解鎖完整頁面
建立帳號並開始 Pro+ 試用，即可開啟 Roflumilast 的完整藥品專論：劑量、懷孕與哺乳、副作用、警示及所有交互作用。
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
在網頁版免費試用 Pro+ 7 天，無需信用卡。
同類別的其他藥品
常見問題
What is Roflumilast used for?
Roflumilast is a medicine in the class respiratory. It is used for COPD, Scalp psoriasis.
What side effects have been reported with Roflumilast?
Headache, Diarrhea, Nausea, Weight loss.
Can Roflumilast be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. No adequate human data. No malformations in rats or rabbits; pregnancy loss, stillbirth and poorer pup survival at 10 to 49 times the human dose, and it disrupted labour in mice. EU label: not recommended in pregnancy; US: do not use during labour and delivery. Breastfeeding: Unknown. No human data; it passes into rat milk. US and EU labels: should not be used while breastfeeding. LactMed: over 97% protein bound, so milk levels are probably very low, but the oral drug is best avoided. Cream: use on small areas only, not on the breast.
What does Roflumilast interact with?
MediHelp lists 64 known interactions for Roflumilast. Major: 12 · Moderate: 41 · Minor: 11. The most serious include Apalutamide, Carbamazepine, Efavirenz.
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