藥物交互作用
Phenytoin + Sofosbuvir-velpatasvir-voxilaprevir
嚴重程度: 禁忌併用
Phenytoin and Sofosbuvir-velpatasvir-voxilaprevir: contraindicated interaction.
最後更新
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摘要
Phenytoin induces CYP3A4, CYP2B6 and P-gp and is expected to substantially lower exposure to sofosbuvir, velpatasvir and voxilaprevir. This risks virologic failure. Labeling recommends against use together.
用白話說明這項交互作用的意義
Phenytoin and Sofosbuvir-velpatasvir-voxilaprevir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Phenytoin belongs to Central Nervous System; Sofosbuvir-velpatasvir-voxilaprevir belongs to Anti Virals.
為什麼會發生
Induction of CYP enzymes and P-glycoprotein by phenytoin reduces absorption and increases clearance of the antiviral components.
處置方式
Do not coadminister; change to a non-inducing antiepileptic before starting HCV therapy.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Sofosbuvir-velpatasvir-voxilaprevir 的其他交互作用
- Fosphenytoin + Sofosbuvir-velpatasvir-voxilaprevir 禁忌併用
- Phenobarbital + Sofosbuvir-velpatasvir-voxilaprevir 禁忌併用
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir 禁忌併用
- Rifampin + Sofosbuvir-velpatasvir-voxilaprevir 禁忌併用
- Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir 禁忌併用
- Sofosbuvir-velpatasvir-voxilaprevir + St john's wort 禁忌併用
Phenytoin 的其他交互作用
常見問題
Can I take Phenytoin with Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp rates the interaction as contraindicated. Phenytoin and Sofosbuvir-velpatasvir-voxilaprevir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Phenytoin induces CYP3A4, CYP2B6 and P-gp and is expected to substantially lower exposure to sofosbuvir, velpatasvir and voxilaprevir. This risks virologic failure. Labeling recommends against use together.
How serious is the interaction between Phenytoin and Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; change to a non-inducing antiepileptic before starting HCV therapy.
What other medicines interact with Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp also lists interactions of Sofosbuvir-velpatasvir-voxilaprevir with, for example, Fosphenytoin, Phenobarbital, Primidone. The full list is on the Sofosbuvir-velpatasvir-voxilaprevir page.
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