藥物交互作用
Valoctocogene roxaparvovec + Valproic acid
嚴重程度: 嚴重
Valoctocogene roxaparvovec and Valproic acid: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Valoctocogene roxaparvovec commonly causes transaminase elevations, and valproate is also hepatotoxic. Concurrent use may increase liver injury and may reduce the response to gene therapy.
用白話說明這項交互作用的意義
Valoctocogene roxaparvovec and Valproic acid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Valoctocogene roxaparvovec belongs to Miscellaneous; Valproic acid belongs to Central Nervous System.
為什麼會發生
Additive hepatotoxicity from two hepatotoxic agents.
處置方式
Monitor liver enzymes frequently after infusion and consider an alternative anticonvulsant if feasible. Manage any transaminase rise according to the gene therapy protocol.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Valproic acid 的其他交互作用
Valoctocogene roxaparvovec 的其他交互作用
常見問題
Can I take Valoctocogene roxaparvovec with Valproic acid?
MediHelp rates the interaction as major. Valoctocogene roxaparvovec and Valproic acid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Valoctocogene roxaparvovec commonly causes transaminase elevations, and valproate is also hepatotoxic. Concurrent use may increase liver injury and may reduce the response to gene therapy.
How serious is the interaction between Valoctocogene roxaparvovec and Valproic acid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes frequently after infusion and consider an alternative anticonvulsant if feasible. Manage any transaminase rise according to the gene therapy protocol.
What other medicines interact with Valproic acid?
MediHelp also lists interactions of Valproic acid with, for example, Ertapenem, Imipenem / cilastatin / relebactam, Imipenem / cilastatin. The full list is on the Valproic acid page.
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