藥物交互作用
Sepiapterin + Sildenafil
嚴重程度: 中度
Sepiapterin and Sildenafil: moderate interaction.
最後更新
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摘要
Sepiapterin increases BH4, which supports nitric oxide synthase activity and may enhance vasodilation. Combined with sildenafil, which prolongs cGMP signalling, this may cause additive blood pressure lowering and symptomatic hypotension.
用白話說明這項交互作用的意義
Sepiapterin and Sildenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sepiapterin belongs to Miscellaneous; Sildenafil belongs to Genitourinary.
為什麼會發生
Additive vasodilation through enhanced nitric oxide synthesis (BH4 cofactor) and PDE5 inhibition.
處置方式
Monitor blood pressure and symptoms of hypotension such as dizziness or syncope when starting or adjusting either drug. Counsel patients to report lightheadedness.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Sepiapterin 的其他交互作用
Sildenafil 的其他交互作用
常見問題
Can I take Sepiapterin with Sildenafil?
MediHelp rates the interaction as moderate. Sepiapterin and Sildenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sepiapterin increases BH4, which supports nitric oxide synthase activity and may enhance vasodilation. Combined with sildenafil, which prolongs cGMP signalling, this may cause additive blood pressure lowering and symptomatic hypotension.
How serious is the interaction between Sepiapterin and Sildenafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and symptoms of hypotension such as dizziness or syncope when starting or adjusting either drug. Counsel patients to report lightheadedness.
What other medicines interact with Sepiapterin?
MediHelp also lists interactions of Sepiapterin with, for example, Methotrexate, Pemetrexed, Sulphasalazine. The full list is on the Sepiapterin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
