藥物交互作用
Thalidomide + Vincristine
嚴重程度: 嚴重
Thalidomide and Vincristine: major interaction.
最後更新 來源: UK SmPC
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摘要
Vincristine commonly causes dose-limiting peripheral and autonomic neuropathy, and thalidomide adds further neurotoxic risk. The combination can cause more severe neuropathy and constipation or ileus.
用白話說明這項交互作用的意義
Thalidomide and Vincristine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Thalidomide belongs to Miscellaneous; Vincristine belongs to Oncology.
為什麼會發生
Additive peripheral and autonomic neurotoxicity.
處置方式
Assess neuropathy and bowel function at every cycle and adjust or interrupt vincristine or thalidomide at early signs of progression. Use a prophylactic bowel regimen.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
參考資料
Thalidomide 的其他交互作用
Vincristine 的其他交互作用
常見問題
Can I take Thalidomide with Vincristine?
MediHelp rates the interaction as major. Thalidomide and Vincristine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Vincristine commonly causes dose-limiting peripheral and autonomic neuropathy, and thalidomide adds further neurotoxic risk. The combination can cause more severe neuropathy and constipation or ileus.
How serious is the interaction between Thalidomide and Vincristine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess neuropathy and bowel function at every cycle and adjust or interrupt vincristine or thalidomide at early signs of progression. Use a prophylactic bowel regimen.
What other medicines interact with Thalidomide?
MediHelp also lists interactions of Thalidomide with, for example, Bortezomib, Carbamazepine, Griseofulvin. The full list is on the Thalidomide page.
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