藥品參考

Thalidomide

Thalidomide is a medicine in the class miscellaneous. It is used for multiple myeloma.

藥物類別: Miscellaneous
用途: multiple myeloma

最後更新 29 十月 2026 來源: US FDA label

僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。

本頁的臨床內容僅提供英文版。

重點資訊

藥物類別: Miscellaneous
ATC 代碼: L04AX02
常見劑型: 膠囊
已知交互作用: 41 (嚴重: 9 · 中度: 29 · 輕微: 3)
商品名: 3
國家與市場: 2

劑型、規格與商品名稱會因國家而異。請核對您手上的產品。

用途

Multiple myeloma

作用方式

Mechanism not fully understood. Acts through cereblon, a component of a cullin ring E3 ubiquitin ligase complex; has immunomodulatory, anti-inflammatory and antiangiogenic properties.

成人常用劑量（仿單摘要）

Newly diagnosed multiple myeloma (with dexamethasone): 200 mg orally once daily in 28-day cycles, with water, preferably at bedtime and at least 1 hour after the evening meal; dexamethasone 40 mg daily on days 1-4, 9-12 and 17-20 every 28 days

僅摘錄仿單中第一行劑量說明；完整的劑量內容請見 App。

懷孕與哺乳

懷孕: Unsafe Contraindicated: a powerful human teratogen; even one dose can cause severe limb, ear, eye, heart and other defects, and about 40% of affected infants die at or soon after birth. Only within a pregnancy-prevention programme: contraception from 4 weeks before to 4 weeks after; men use condoms.
哺乳: Unsafe No human milk data; high levels were found in rabbit milk. Because of possible serious reactions in the infant, do not breastfeed during treatment (US label); LactMed: the manufacturer and professional guidelines recommend against breastfeeding.

已通報的副作用

Fatigue
Hypocalcemia
Edema
Constipation
Sensory neuropathy
Dyspnea

黑框警語

Embryo-fetal toxicity: can cause severe birth defects or embryo-fetal death, even with a single capsule. Must never be used by females who are or could become pregnant. Exclude pregnancy before treatment and use two reliable contraception methods. Available only through the THALOMID REMS program.

禁忌症

Pregnancy
Demonstrated hypersensitivity to the drug or its components

哪些人需要特別留意

Venous and arterial thromboembolism, including ischemic heart disease, MI and stroke, with dexamethasone
Increased mortality when pembrolizumab is added to a thalidomide analogue plus dexamethasone in MM; not recommended outside controlled trials
Frequent drowsiness and somnolence; avoid hazardous tasks and other sedating drugs

請告知藥師或醫師您是否懷孕或哺乳、是否患有腎臟或肝臟疾病、是否有過敏，以及您正在使用的所有其他藥物或保健品。

重要交互作用 (41)

All 41 interactions, with severity and what to do

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Dosing by age, kidney and liver function, and further dose lines
Renal and hepatic dose adjustments
Dosing in older adults
How to give it
Pharmacokinetics
Patient counselling points
Food interactions

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同類別的其他藥品

常見問題

What is Thalidomide used for?

Thalidomide is a medicine in the class miscellaneous. It is used for Multiple myeloma.

What side effects have been reported with Thalidomide?

Fatigue, Hypocalcemia, Edema, Constipation, Sensory neuropathy, Dyspnea. Serious warning: Embryo-fetal toxicity: can cause severe birth defects or embryo-fetal death, even with a single capsule.

Can Thalidomide be taken in pregnancy or while breastfeeding?

Pregnancy: Unsafe. Contraindicated: a powerful human teratogen; even one dose can cause severe limb, ear, eye, heart and other defects, and about 40% of affected infants die at or soon after birth. Only within a pregnancy-prevention programme: contraception from 4 weeks before to 4 weeks after; men use condoms. Breastfeeding: Unsafe. No human milk data; high levels were found in rabbit milk. Because of possible serious reactions in the infant, do not breastfeed during treatment (US label); LactMed: the manufacturer and professional guidelines recommend against breastfeeding.

What does Thalidomide interact with?

MediHelp lists 41 known interactions for Thalidomide. Major: 9 · Moderate: 29 · Minor: 3. The most serious include Bortezomib, Carbamazepine, Griseofulvin.

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