藥物交互作用
Carbamazepine + Thalidomide
嚴重程度: 嚴重
Carbamazepine and Thalidomide: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Carbamazepine is an enzyme inducer that lowers hormonal contraceptive concentrations and can result in breakthrough ovulation. With thalidomide, contraceptive failure risks severe fetal malformations.
用白話說明這項交互作用的意義
Carbamazepine and Thalidomide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Carbamazepine belongs to Central Nervous System; Thalidomide belongs to Miscellaneous.
為什麼會發生
CYP3A4 induction by carbamazepine accelerates metabolism of contraceptive hormones.
處置方式
Do not rely on hormonal contraceptives; use a copper IUD or other non-hormonal highly effective method with a barrier method during and after carbamazepine.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Thalidomide 的其他交互作用
Carbamazepine 的其他交互作用
常見問題
Can I take Carbamazepine with Thalidomide?
MediHelp rates the interaction as major. Carbamazepine and Thalidomide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Carbamazepine is an enzyme inducer that lowers hormonal contraceptive concentrations and can result in breakthrough ovulation. With thalidomide, contraceptive failure risks severe fetal malformations.
How serious is the interaction between Carbamazepine and Thalidomide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not rely on hormonal contraceptives; use a copper IUD or other non-hormonal highly effective method with a barrier method during and after carbamazepine.
What other medicines interact with Thalidomide?
MediHelp also lists interactions of Thalidomide with, for example, Bortezomib, Griseofulvin, Modafinil. The full list is on the Thalidomide page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
