藥物交互作用
Bortezomib + Thalidomide
嚴重程度: 嚴重
Bortezomib and Thalidomide: major interaction.
最後更新 來源: UK SmPC
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摘要
Both drugs cause peripheral neuropathy, and combining them in myeloma regimens increases the frequency and severity of nerve damage. Neuropathy may become disabling and persistent if not recognized early.
用白話說明這項交互作用的意義
Bortezomib and Thalidomide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bortezomib belongs to Oncology; Thalidomide belongs to Miscellaneous.
為什麼會發生
Additive neurotoxicity affecting peripheral sensory nerves.
處置方式
Assess neuropathy symptoms before each cycle and reduce the dose, delay or stop the offending drug when neuropathy worsens. Consider subcutaneous bortezomib dosing and weekly schedules to lower risk.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
參考資料
Thalidomide 的其他交互作用
Bortezomib 的其他交互作用
常見問題
Can I take Bortezomib with Thalidomide?
MediHelp rates the interaction as major. Bortezomib and Thalidomide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs cause peripheral neuropathy, and combining them in myeloma regimens increases the frequency and severity of nerve damage. Neuropathy may become disabling and persistent if not recognized early.
How serious is the interaction between Bortezomib and Thalidomide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess neuropathy symptoms before each cycle and reduce the dose, delay or stop the offending drug when neuropathy worsens. Consider subcutaneous bortezomib dosing and weekly schedules to lower risk.
What other medicines interact with Thalidomide?
MediHelp also lists interactions of Thalidomide with, for example, Carbamazepine, Griseofulvin, Modafinil. The full list is on the Thalidomide page.
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